The Monophasic Action Potential in Clinical Cardiology
- 1 June 1991
- journal article
- review article
- Published by Wiley in Clinical Cardiology
- Vol. 14 (6) , 505-510
- https://doi.org/10.1002/clc.4960140610
Abstract
Summary: For more than 30 years, the monophasic action potential has been used as an experimental tool for the study of myocardial repolarization. With recent improvements in catheter design, the utility of the tool as a means to identify the bases for ventricular arrhythmias in humans has been greatly improved. Abnormalities of repolarization leading to ventricular arrhythmia formation can be identified and specific pharmacologic therapies may be evaluated. Further evaluation of the technique by cardiac electrophysiologists may improve both the diagnosis and the treatment of ventricular arrhythmias dependent upon afterdepolarization formation (acquired and familial long QT syndromes).Keywords
This publication has 18 references indexed in Scilit:
- Ventricular Tachyarrhythmias Related to Early Afterdepolarizations and Triggered Firing: Relationship to QT Interval Prolongation and Potential Therapeutic Role for Calcium Channel Blocking AgentsJournal of Cardiovascular Electrophysiology, 1990
- Early and Delayed Afterdepolarizations Associated with Cesium Chloride-Induced Arrhythmias in the DogJournal of Cardiovascular Pharmacology, 1990
- Quinidine-induced long qtu interval and torsade de pointes: Role of bradycardia-dependent early afterdepolarizationsJournal of the American College of Cardiology, 1989
- Acute effects of smoking one cigarette on monophasic action potentials and intraventricular conduction in coronary artery diseaseThe American Journal of Cardiology, 1989
- Comparison of the effects of chronic oral therapy with atenolol and sotalol on ventricular monophasic action potential duration and effective refractory periodAmerican Heart Journal, 1988
- Autonomic modulation of ventricular arrhythmia in cesium chloride-induced long QT syndrome.Circulation, 1988
- Relation of monophasic action potential recorded with contact electrode to underlying transmembrane action potential properties in isolated cardiac tissues: a systematic microelectrode validation studyCardiovascular Research, 1988
- Cesium chloride-induced long QT syndrome: demonstration of afterdepolarizations and triggered activity in vivo.Circulation, 1985
- Long-term recording of monophasic action potentials from human endocardiumThe American Journal of Cardiology, 1983
- Prolongation of the human cardiac monophasic action potential by sotalolThe American Journal of Cardiology, 1982