The Dosage of Chloromycetin Palmitate in Children

Publisher Website
Google Scholar
Abstract
SummaryParke‐Davis' palatable Chloromycetin palmitate was tested. It is easily taken by young children, in contrast to the extremely repulsive crystalline Chloromycetin (chloramphenicol). The absorption rate for Chloromycetin palmitate is slower than that for crystalline Chloromycetin and the maximum blood concentration, which for crystalline Chloromycetin is obtained about 2 hours after the fasting administration, is not reached until 1 hour later for Chloromycetin palmitate. A further retardation of absorption takes place if the drug is not administered fasting. The maximum blood concentration of crystalline Chloromycetin is three times higher than the maximum values for the palmitate of the same dosage. Control experiments show that the Chloromycetin palmitate dosage should be three times greater than that of crystalline Chloromycetin in order to obtain the same maximum blood concentrations. For the maintenance of a lowest blood concentration of Chloromycetin of about 5 γ/ml, a Chloromycetin palmitate dose of 200 mg/kg per 24 hours, administered in 4 doses, is required. In order to obtain a more rapid initial rise of the blood concentration the first dose of Chloromycetin palmitate should be given with a single dose of crystalline Chloromycetin (approx. 15 mg/kg).

This publication has 1 reference indexed in Scilit: