Cellular Specificity of Plasmacytoma-Induced Immunosuppression
Open Access
- 1 August 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 117 (2) , 563-568
- https://doi.org/10.4049/jimmunol.117.2.563
Abstract
The pattern of immunodeficiency in plasmacytoma-bearing mice appears to be unique. Mice bearing these tumors exhibit a severe impairment in their ability to mount a primary immune response to thymus-dependent and -independent antigens. However, cell-mediated immune functions in these mice apparently remain intact. Thus, when T cell activity of lymph node cells from plasmacytomabearing mice was tested in vivo by sensitization with dinitrofluorobenzene and in vitro by responsiveness to phytohemagglutinin, allogeneic cells, and dinitrobenzene sulfonate, cell-mediated immunity was found to be normal.This publication has 1 reference indexed in Scilit: