CARDIOVASCULAR-RESPONSE TO FENTANYL-DROPERIDOL AND ATROPINE IN DOG

  • 1 January 1977
    • journal article
    • research article
    • Vol. 38  (4) , 479-482
Abstract
A combination of fentanyl-droperidol was administered i.v. alone or with atropine sulfate (2 doses, 0.04 or 0.02 mg/kg body wt) to determine if stable neuroleptanalgesia could be produced in the dog. Cardiovascular responses were recorded at 5, 15 and 30 min. Fentanyl-droperidol given alone caused a significant increase of peripheral resistance and mean arterial pressure at 5 min and then a decrease of these values over a postinjection period of 30 min. Left ventricular dP/dt [change in pressure with time] increased significantly at postinjection minutes 15 and 30. In dogs given atropine concurrently with fentanyl-droperidol, there was significant increase in heart rate and decrease in stroke volume. Also, there were significant initial increases in diastolic and mean arterial blood pressures, ventricular contractility and coronary blood flow. The dose of 0.02 mg of atropine/kg seemed optimal for i.v. administration with fentanyl-droperidol in the dog; when the atropine dose was 0.04 mg/kg, large inotropic and chronotropic effects were produced.

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