EFFECT OF A PROLINE-RICH POLYPEPTIDE ON DONOR CELLS IN GRAFT VERSUS HOST-REACTION

  • 1 January 1982
    • journal article
    • research article
    • Vol. 47  (1) , 141-147
Abstract
The effect of a proline-rich polypeptide (PRP) isolated from early sheep colostrum on the graft-vs.-host (GvH) reaction [in mice] was studied. Unfractionated thymocytes, treated with PRP in vivo or in vitro, acquired the ability to elicit the GvH reaction. PRP elicited GvH reactivity in cortisone-sensitive thymocytes and cortisone-sensitive thymocytes become cortisone-resistant after incubation with PRP. Some of the cortisone-resistant thymocytes became cortisone-sensitive when treated with PRP and the ability to induce the GvH reaction was reduced.