Treatment of Mouse Muscular Dystrophy with the Protease Inhibitor Pepstatin
- 1 May 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Neuropathology and Experimental Neurology
- Vol. 37 (3) , 263-268
- https://doi.org/10.1097/00005072-197805000-00004
Abstract
Dystrophic mice were treated for 5 weeks beginning at 3 weeks of age with 20 ugm per day of pepstatin, a potent inhibitor of cathepsin D. Mortality was less and weight gain greater in pepstatin treated mice than in controls. Muscle bulk was greater and hind lamb contractures were reduced in treated mice. Mean muscle fiber mass was significantly increased by pepstatin treatment. Inhibition of muscle protease may be the mechanism by which pepstatin slows the tempo of progression of mouse muscular dystrophy.This publication has 4 references indexed in Scilit:
- The inhibition by pepstatin of cathepsin D and autolysis of dystrophic muscleLife Sciences, 1976
- Increased lysosomal enzymes in genetic muscular dystrophyArchives of Biochemistry and Biophysics, 1962
- Histopathology of hereditary, progressive muscular dystrophy in inbred strain 129 miceThe Anatomical Record, 1960
- Enzyme Studies in Muscular Dystrophy. III. In Hereditary Muscular Dystrophy in Mice.Experimental Biology and Medicine, 1958