Vitamin A Intake and Hip Fractures Among Postmenopausal Women
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Open Access
- 2 January 2002
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 287 (1) , 47-54
- https://doi.org/10.1001/jama.287.1.47
Abstract
Ingestion of toxic amounts of vitamin A has long been known to have adverse skeletal effects.1,2 In animals, retinoic acid suppresses osteoblast activity,3 stimulates osteoclast formation,4 and antagonizes the ability of vitamin D to maintain normal serum calcium levels,5 all of which may contribute to the accelerated bone resorption and fractures observed with hypervitaminosis A.6 In humans, long-term ingestion of high amounts of vitamin A can lead to hypercalcemia and bone abnormalities.7 In addition, lower bone mass8 and decreased biochemical markers for bone turnover9 have been observed in patients treated with retinoids for skin diseases.Keywords
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