Clinical limitations of the estimation of glomerular filtration rate from height/plasma creatinine ratio: a comparison with simultaneous 51Cr edetic acid slope clearance.

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Abstract
A retrospective comparison of single determinations of glomerular filtration rate measured by 51Cr-edetic acid slope clearance (CEDTA) and height/plasma creatinine ratio (Ht/PC) was undertaken in 199 children aged 3-16 yr. Only if Ht/PC .ltoreq. 1.2 cm/.mu.mol per 1 was the relationship between Ht/PC and CEDTA linear. Over this range where renal function is significantly impaired the confidence limits for individual prediction of glomerular filtration rate were so wide that a definitive measurement of renal function would be necessary in clinical practice. Where Ht/PC .gtoreq. 1.2 the relationship was nonlinear and the predictive confidence limits very wide. To apply the technique as a screening test for normal renal function (CEDTA .gtoreq. 80 ml/min per 1.73 m2), the Ht/PC would need to exceed 2.16. This would have detected 57 of 131 patients who had normal glomerular filtration rates and erroneously included 2 of 68 with subnormal renal function.