Ophthalmoplegia in Acute Polyneuritis

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Abstract
INVOLVEMENT of the extraocular muscles in acute infectious polyneuritis is well recognized, but complete external ophthalmoplegia is rare and involvement of the pupils even more rare. Patients with unusual combinations of signs have been described separately from the main group of patients with acute infectious polyneuritis. For example, in polyneuritis cranialis, the lesions are confined to the cranial nerves, and Fisher1 described another group of cases with ophthalmoplegia, ataxia, and loss of reflexes. This paper describes several patients with ophthalmoplegia and shows that there is a wide variation in the type of ophthalmoplegia and in the associated limb involvement in acute polyneuritis. Epidemiology Patients 1, 2, 5, and 6 fell ill in 1963 or the first two months of 1964 and lived in London. They were seen in three hospitals specializing in neurology and were referred because of unusual clinical features. During the same period, 25 other patients with

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