Postnatal Development of Renal Concentration Capacity as Estimated by DDAVP-Test in Normal and Asphyxiated Neonates

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Abstract
Postnatal development of renal concentration capacity was estimated by longitudinal studies in capacity 20 healthy term and preterm neonates and 8 asphyxiated neonates. The response curve during the renal concentration test was shorter in all infants at 1–3 weeks of age, especially in preterm infants. The mean maximum urine osmolality values during renal concentration test in non-asphyxiated term and preterm neonates and asphyxiated neonates were 385, 359, and 300 mOsm/kg, respectively, at 1–3 weeks of age, but 565, 524, and 525 mOsm/kg, respectively, at 4–6 weeks of age, i.e. a significant lowered capacity in the asphyxiated neonates at 1–3 weeks of age.

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