Critical Evaluation of Massive Steroid Therapy of Acute Leukemia

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Abstract
THE fact that adrenocortical hormones can be of considerable benefit in acute leukemia has long been recognized. In recent years a number of investigators have attempted to enhance the effectiveness of these hormones by administering massive doses.1 2 3 4 5 6 7 8 9 The individual series reported, however, have generally been small, and the type of leukemia has not always been clearly classified. It was the purpose of this study to evaluate the efficacy of massive steroid therapy in acute leukemia and to observe any variations in the effectiveness of adrenocortical hormones in different types of leukemia. Preliminary observation had led us to believe that further . . .