Cardiometabolic Risk of Second-Generation Antipsychotic Medications During First-Time Use in Children and Adolescents
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Open Access
- 28 October 2009
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 302 (16) , 1765-1773
- https://doi.org/10.1001/jama.2009.1549
Abstract
Second-generation antipsychotic medications are commonly and increasingly prescribed to children and adolescents in the United States as first-line treatment for psychotic disorders, bipolar disorder, and nonpsychotic mental disorders.1 Increasingly, the cardiometabolic effects of second-generation antipsychotic medications have raised concern.2 Cardiometabolic adverse effects, such as age-inappropriate weight gain, obesity, hypertension, and lipid and glucose abnormalities, are particularly problematic during development because they predict adult obesity, the metabolic syndrome, cardiovascular morbidity, and malignancy.3-6Keywords
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