Cytochrome P-450-dependent H2O2production demonstrated in vivo
- 7 April 1986
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 199 (1) , 19-22
- https://doi.org/10.1016/0014-5793(86)81215-7
Abstract
By administration of allylisopropylacetamide, an inhibitor of cytochrome P-450, we demonstrated that cytochrome P-450 is involved in the production of H2O2 during aminopyrine metabolism and phenobarbital induction in both the unanaesthetized guinea pig and rat. In the guinea pig we also found evidence for the existence of a basal cytochrome P-450-dependent H2O2 production, i.e. in the absence of exogenous substrate. Catalase participates in the decomposition of H2O2 produced in the endoplasmic reticulum where cytochrome P-450 is localized.Keywords
This publication has 13 references indexed in Scilit:
- Thioridazine: a selective inhibitor of peroxisomal β‐oxidation in vivoFEBS Letters, 1985
- Peroxisomal β-oxidation from endogenous substrates. Demonstration through H2O2 production in the unanaesthetized mouseBiochemical Journal, 1984
- The degradation of different forms of cytochrome P-450 in vivo by fluroxene and allyl-iso-propylacetamideBiochemical and Biophysical Research Communications, 1978
- Hydrogen peroxide formation and stoichiometry of hydroxylation reactions catalyzed by highly purified liver microsomal cytochrome P-450Archives of Biochemistry and Biophysics, 1977
- ALTERATIONS OF HEPATIC MICROSOMAL MIXED FUNCTION OXYGENASE DEPENDENT H2O2 FORMATION DUE TO “UNCOUPLING” AND INDUCTION AS DEMONSTRATED IN VIVO BY ELIMINATION KINETICS OF ETHANOL IN GUINEA PIGPublished by Elsevier ,1977
- Mono-oxygenase-Linked Hydrogen Peroxide Production and Degradation in Liver Microsomal FractionsBiochemical Society Transactions, 1975
- [36] Isolation of rat liver peroxisomesPublished by Elsevier ,1974
- Possible control of hydrogen peroxide production and degradation in microsomes during mixed function oxidation reactionBiochemical and Biophysical Research Communications, 1973
- Hepatic Microsomal Ethanol OxidationEuropean Journal of Biochemistry, 1972
- ROLE OF THE INTRACELLULAR DISTRIBUTION OF HEPATIC CATALASE IN THE PEROXIDATIVE OXIDATION OF METHANOLAnnals of the New York Academy of Sciences, 1969