Effect of organic vehicles on the pharmacokinetics of aminophylline administered intravenously to goats
- 1 June 1987
- journal article
- research article
- Published by Wiley in Journal of Veterinary Pharmacology and Therapeutics
- Vol. 10 (2) , 144-149
- https://doi.org/10.1111/j.1365-2885.1987.tb00091.x
Abstract
Davis, L.E., Neff‐Davis, C.A., Koritz, G.D., Bevill, R.F., Sharma, G.C., Langston, V.C. & Munsiff, I.J. Effect of organic vehicles on the pharmacokinetics of aminophylline administered intravenously to goats.J, vet. Pharmacol. Therap. 10, 144–149.Aminophylline dissolved in water, propylene glycol, or dimethyl sulfoxide was administered intravenously to goats in a randomized cross‐over experiment. Model‐dependent and model‐independent pharmacokinetic parameters for theophylline were compared on the basis of the solvent used in the dosage form administered. No difference was found in any pharmacokinetic parameter. Thus, we found no evidence for the possibility that the organic solvents studied would confound pharmacokinetic investigations of theophylline and similar lipophilic drugs.This publication has 21 references indexed in Scilit:
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