THE TOXIC FACTORS IN EXPERIMENTAL TRAUMATIC SHOCK. I. PHYSIOLOGIC EFFECTS OF MUSCLE LIGATION IN THE DOG 1

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Abstract
A method is described for the production of ischemic damage in a reproducible way to a known amt. of muscle (triceps surae) with subsequent re-establishment of circulation. The amt. of tissue involved comprised about 1% of body wt. This method occasionally produces shock (3 of 10 cases) when uncombined with other procedures detrimental to the circulation. Both local exudation of fluid and absorption of muscle constituents into the blood stream follow the removal of tourniquets. Quantitative collection of muscle exudate can be accomplished by this technique by placing a rubber sheath around the muscle mass. It is therefore possible to assay the relative roles of these 2 factors in the production of shock by a reproducible traumatic procedure. Intravenous saline transfusions increase the amt. of fluid exudation from traumatized tissue. Advantages of a quantitative method of this type in the critical study of traumatic shock are discussed.

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