A Proposed Comprehensive Pathophysiology of Thrombotic Thrombocytopenic Purpura With Implicit Novel Tests and Therapies

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Abstract
The first detailed comprehensive hypothesis for the pathophysiology of TTP is proposed which accounts for all of the features of TTP at several levels of reference: clinical, physiologic, biochemical, hematologic, and tissue pathology. From the proposed pathophysiology, by deduction, a number of novel diagnostic tests and several rational, promising therapeutic modalities.

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