ALTERED IMMUNOCHEMICAL HETEROGENEITY OF CALCITONIN INDUCED BY CALCIUM INFUSION

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Abstract
The heterogeneity of iCT [immunoreactive calcitonin] in response to Ca infusion was investigated. The magnitude of iCT response in normal [human] subjects depends on the rate of Ca infusion. For subjects with low basal levels, the principal increase was in fraction IV. For patients with MTC [medullary thyroid cancer] there was an increase in all fractions, especially IV and V; this increase depends on overall magnitude of response and time of sampling. The forms of iCT appearing in response to induced hypercalcemia are principally low MW fractions. Although the proportion of iCT fractions changes initially during infusion, the basal profile is often rapidly restored.

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