Forefront of Na+/Ca2+ Exchanger Studies: Role of Na+/Ca2+ Exchanger – Lessons From Knockout Mice

1 January 2004

journal article
research article
Published by Japanese Pharmacological Society in Journal of Pharmacological Sciences

Vol. 96 (1) , 23-26
https://doi.org/10.1254/jphs.fmj04002x5

Abstract

We used Na+/Ca2+ exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury. The contractile function in NCX KO mice hearts was significantly better than that in wild type (WT) mouse hearts after ischemia/reperfusion and the infracted size was significantly smaller in NCX KO mice hearts compared with that in WT mice hearts. NCX is critically involved in the development of ischemia/reperfusion-induced myocardial injury, and therefore the inhibition of NCX function may contribute to cardioprotection against ischemia/reperfusion injury.

Keywords

This publication has 19 references indexed in Scilit:

Knockout Mice for Pharmacological Screening
Circulation Research, 2002
Antisense inhibition of Na⁺/Ca²⁺exchange during anoxia/reoxygenation in ventricular myocytes
American Journal of Physiology-Heart and Circulatory Physiology, 2001
Inhibition of Na+/Ca2+ exchange by KB-R7943, a novel selective antagonist, attenuates phosphoethanolamine and free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury
Brain Research, 2001
Functional Roles of Cardiac and Vascular ATP-Sensitive Potassium Channels Clarified by Kir6.2-Knockout Mice
Circulation Research, 2001
Targeted Disruption of Na+/Ca2+ Exchanger Gene Leads to Cardiomyocyte Apoptosis and Defects in Heartbeat
Published by Elsevier ,2000
Inhibitory effect of amiodarone on Na⁺/Ca²⁺ exchange current in guinea‐pig cardiac myocytes
British Journal of Pharmacology, 2000
Sodium/calcium exchanger in heart muscle: molecular biology, cellular function, and its special role in excitation-contraction coupling
Cardiovascular Research, 1993
The Relationship Between Charge Movements Associated with I _Ca and I _Na-Ca in Cardiac Myocyte
Science, 1990
Identification of sodium‐calcium exchange current in single ventricular cells of guinea‐pig.
The Journal of Physiology, 1987
Resting membrane potential, extracellular potassium activity, and intracellular sodium activity during acute global ischemia in isolated perfused guinea pig hearts.
Circulation Research, 1983