EXPERIMENTAL-STUDY OF THE INFLUENCE OF POROSITY ON DEVELOPMENT OF NEOINTIMA IN GORE-TEX GRAFTS - A METHOD TO INCREASE LONG-TERM PATENCY RATE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 47  (8) , 347-354
Abstract
The controlled microscopic development and fate of the neointima of Gore-Tex graft pretreated with multiple regular perforations were compared to nonperforated controls. Gore-Tex grafts (each 7 cm .times. 8 mm), perforated at regular 2-min intervals with a special needle (0.8 mm internal diameter) for 1/2 the length, with the remaining half kept intact, were implanted in 37 canine abdominal aortas in an end-to-end fashion. Standard untreated Gore-Tex grafts, of identical size, were similarly implanted in 10 as controls. The perforated portion of the artificially treated Gore-Tex grafts demonstrated early neointimization at 1 wk, the presence of fibroblasts and developing vasovasorum at 4 wk and complete endothelialization at 12 wk. The unperforated portion of implanted grafts demonstrated delayed endothelialization, requiring 24 wk for complete development. Untreated controls demonstrated incomplete healing of the central luminal portion of the graft, with reddish thrombi still present at 24 wk. The poor development of neointima persists in the central portion of standard Gore-Tex controls in the late postoperative period, while pretreatment with multiple small perforations significantly hastens the development of a smooth neointima.

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