THE EFFECT OF INTRAVENOUS AND INTRAPERITONEAL INJECTIONS OF IRRADIATED ERGOSTEROL

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Abstract
In experiments on 14 dogs irradiated ergosterol, in-traven. or intraperitoneally, was more effective than comparable doses by mouth. The alimentary tract protects to some extent against the toxic effects of large doses. Present available evidence indicates that the induction of toxic symptoms is not necessarily parallel with hypercalcemia. Present evidence does not indicate any constant effect of ergosterol when administered by this method on the concentration of inorganic P in the blood. Continued administration of a therapeutic dose of ergosterol may develop in the normal animal a certain degree of tolerance as indicated by the reduction of hypercalcemia. Hypercalcemia may persist for long periods after administration has been discontinued. After pronounced toxic symptoms were developed, none of the animals in this series recovered after discontinuance of administration.

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