Biliary excretion and intestinal metabolism in the intermediary metabolism of pentachlorothioanisole
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 20 (6) , 601-605
- https://doi.org/10.3109/00498259009046875
Abstract
1. Biliary metabolites from rats dosed with pentachlorothioanisole (PCTA) were characterized by fast atom bombardment mass spectrometry and electron impact mass spectrometry. 2. Most of the biliary metabolites from PCTA were mercapturic acid pathway metabolites of methylsulphinyltetrachlorobenzene (51% of the dose); the remaining characterized biliary metabolites (20%) were mainly methylsulphinyltetrachlorothio-phenols excreted as unknown conjugates. 3. Pathways are proposed for the intermediary metabolism of PCTA to bis-(methylthio)tetrachlorobenzene (bis-MTTCB) involving glutathione conjugation, biliary excretion, intestinal metabolism, and enterohepatic circulation.This publication has 8 references indexed in Scilit:
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