Two Birds with One Metallic Stone: Single‐Pot Catalysis of Fundamentally Different Transformations
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- 12 July 2004
- journal article
- review article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 43 (29) , 3754-3760
- https://doi.org/10.1002/anie.200301727
Abstract
Advances in metal catalysis have revolutionized organic synthesis, with the scope of metal-catalyzed reactions now covering nearly all areas of carbon–carbon, carbon–hydrogen, and carbon–heteroatom bond formation. For years, the goal was to develop catalysts that were highly selective for a single transformation. However, a promising current area of research is the use of a single catalyst to mediate more than one transformation in a selective manner. Whereas much early work was focused on using a catalyst for several similar transformations, recent investigations have shown that it is also possible to employ a single catalyst for several very different transformations in a single reaction sequence. This Minireview focuses on methods in which the mechanisms of the transformations are fundamentally very different.Keywords
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