Effect of Testosterone on Plasma LH in Male Rats of Various Ages1
- 1 April 1974
- journal article
- other
- Published by The Endocrine Society in Endocrinology
- Vol. 94 (4) , 947-951
- https://doi.org/10.1210/endo-94-4-947
Abstract
In male rats, plasma LH levels were elevated 10 days after castration at 7, 10, 20, 30, 40, 50, 60, and 70 days of age. The effect of replacement therapy with daily injections of testosterone propionate for 10 days was tested in rats castrated at 10, 40, and 70 days of age. In the immature rats castrated at 10 days of age, 6–12 μg/;100 g body wt/day reduced LH levels to normal, while in the adult rats castrated at 70 days of age, it required 25–50 μg/100 g, and in the pubertal group castrated at 40 days of age, it required 50–100 μg/100 g. In the groups castrated at 40 and 70 days of age, 6 μ;g/100 g produced a rise in plasma LH. No such “positive feedback“ was seen in the animals castrated at 10 days of age. (Endocrinology94: 947, 1974)Keywords
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