INFLUENCE OF A HIGHLY PURIFIED THYMUS EXTRACT UPON THE ADRENALS OF GUINEA-PIGS

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Abstract
SUMMARY: 1. An attempt has been made to demonstrate the influence of the thymus upon the adrenal in guinea-pigs by daily injection of unphysiological amounts of a highly purified thymus extract. 2. Such injections caused a marked but transient increase in both the vitamin C and cholesterol content of the adrenal. 3. Morphologically, there was a decrease in the weight of the adrenal cortex relative to that of the whole gland, while the relative weight of the medulla increased correspondingly. This change was not transient, but persisted up to 110 days of treatment. 4. It is concluded that the effect of injecting thymus extract is opposite to that of injecting ACTH and gives rise to a resting condition of the adrenal cortex.

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