Outcome measures in Sjogren's syndrome

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Abstract
Sjögren's syndrome (SS) is a systemic autoimmune disorder characterized by chronic focal lymphocytic inflammation of exocrine tissues leading to glandular dysfunction, in particular the diagnostic features of dry eyes and dry mouth [1]. SS may exist as a primary disorder or can be associated with other autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and progressive systemic sclerosis. The key clinical manifestations of SS are derived from the ocular and oral components as well as from musculoskeletal involvement and fatigue. The ‘systemic’ component of SS relates to B‐cell hyperactivity and disease manifestations from internal organs, the integument and the nervous and haematopoietic systems. Apart from a significantly increased incidence of malignant lymphomas in these patients, systemic features are in general mild or subclinical as opposed to the prominent sicca features [2].

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