Molecular mechanisms in successful peripheral regeneration
- 13 May 2005
- journal article
- review article
- Published by Wiley in The FEBS Journal
- Vol. 272 (11) , 2628-2638
- https://doi.org/10.1111/j.1742-4658.2005.04699.x
Abstract
Peripheral nerve injury is normally followed by a robust regenerative response. Here we describe the early changes associated with injury from the initial rise in intracellular calcium and the subsequent activation of transcription factors and cytokines leading to an inflammatory reaction, and the expression of growth factors, cytokines, neuropeptides, and other secreted molecules involved in cell‐to‐cell communication promoting regeneration and neurite outgrowth. The aim of this review is to summarize the molecular mechanisms that play a part in executing successful regeneration.Keywords
This publication has 143 references indexed in Scilit:
- Inhibition of c-Jun phosphorylation reduces axonal outgrowth of adult rat nodose ganglia and dorsal root ganglia sensory neuronsMolecular and Cellular Neuroscience, 2004
- Activation of cyclin-dependent kinase 5 is involved in axonal regenerationMolecular and Cellular Neuroscience, 2004
- Identification of reciprocally regulated gene modules in regenerating dorsal root ganglion neurons and activated peripheral or central nervous system gliaJournal of Cellular Biochemistry, 2003
- Repair of spinal cord injuries: where are we, where are we going?Spinal Cord, 2002
- SCG10‐related neuronal growth‐associated proteins in neural development, plasticity, degeneration, and agingJournal of Neuroscience Research, 2002
- Cryptic physiological trophic support of motoneurons by LIF revealed by double gene targeting of CNTF and LIFCurrent Biology, 1996
- The expression of CNTF message and immunoreactivity in the central and peripheral nervous system of the ratDevelopmental Brain Research, 1992
- Long-term increase in the levels of c-jun mRNA and jun protein-like immunoreactivity in motor and sensory neurons following axon damageNeuroscience Letters, 1991
- ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neuronsNeuron, 1989
- Ornithine decarboxylase activity in retinal explants of goldfish undergoing optic nerve regenerationDevelopmental Brain Research, 1981