Tumour promoter 12-O-tetradecanoylphorbol 13-acetate and epidermal growth factor stimulate proliferation and inhibit differentiation of porcine thyroid cells in primary culture
- 1 June 1987
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 113 (3) , 485-487
- https://doi.org/10.1677/joe.0.1130485
Abstract
12-O-Tetradecanoylphorbol 13-acetate (TPA) is a potent tumour promoter and shows several biological activities of epidermal growth factor (EGF). EGF and TPA stimulated proliferation and inhibited differentiation of porcine thyroid cells in primary culture. They also stimulated [3H]thymidine incorporation and inhibited an early step in thyroid hormone synthesis (iodine organification). The results indicate that EGF and TPA switch the developmental course of porcine thyroid cells from differentiation to proliferation. J. Endocr. (1987) 113, 485–487This publication has 3 references indexed in Scilit:
- Epidermal Growth Factor Modulates Thyroid Growth and Function in Culture*Endocrinology, 1983
- Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester.Proceedings of the National Academy of Sciences, 1979
- Tumor promoters inhibit spontaneous and induced differentiation of murine erythroleukemia cells in culture.Proceedings of the National Academy of Sciences, 1977