Effect of naloxone administration upon responses of adrenal hormones to withdrawal from ethanol
- 1 January 1984
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 82 (3) , 181-184
- https://doi.org/10.1007/bf00427769
Abstract
Rats maintained on an ethanol-liquid diet developed physical dependence after 16 days. Activation of adrenocortical function and overactivity of the sympathoadrenal system were observed during withdrawal from ethanol. The opiate antagonist naloxone prevented the adrenomedullary response, and attenuated, though not significantly, the increases in serum corticosterone induced by ethanol deprivation. These findings suggest that endogenous opioid pathways may be involved in the ethanol-withdrawal syndrome.This publication has 39 references indexed in Scilit:
- Endogenous opiates: 1981Peptides, 1982
- Adrenal catecholamines in rats after severe ethanol intoxication and acute withdrawalPharmacology Biochemistry and Behavior, 1982
- Ethanol-metrecal diets: I. Effects of different levels of ethanol-derived kilocalories on consumption of diet, body weight and grams of ethanol ingestedPharmacology Biochemistry and Behavior, 1981
- Effect of chronic intoxication and naloxone on the ethanol-induced increase in plasma corticosteroneLife Sciences, 1981
- Opioid peptides in adrenal glandLife Sciences, 1980
- PREVENTION OF EFFECTS OF ALCOHOL INTOXICATION BY NALOXONEThe Lancet, 1979
- On the specificity of naloxone as an opiate antagonistLife Sciences, 1979
- β-Endorphin and Adrenocorticotropin Are Selected Concomitantly by the Pituitary GlandScience, 1977
- Induction of physical dependence of ethanol in rhesus monkeys using an oral acceptance techniqueLife Sciences, 1972
- The simultaneous fluorimetric determination of corticosterone and cortisol in plasmaSteroids, 1967