DETERMINATION OF BRONCHOSPASM IN THE GUINEA-PIG

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Abstract
In continuation of studies on the production of amines1 by bacteria, we desired physiologic methods to supplement the chemical methods that are now being used in this laboratory2 for the assay of bacterial filtrates. The marked action of amines on smooth muscle, causing violent contractions, forms the basis of such physiologic methods. The adaptation of this action on the smooth muscle of isolated arteries provided one such method, the technic of which is described in a later article. The present article is concerned with still another method, based on the action of amines on the smooth muscle of the bronchi. The various methods that have been previously used for the demonstration of bronchospasm are of two types. The first type makes use of isolated bronchial rings or strips mounted in a suitable medium so that contractions of their muscle are registered by an appropriate lever on a smoked drum. This

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