STEROID PROFILE OF A VIRILIZING OVARIAN TUMOR

  • 1 January 1978
    • journal article
    • research article
    • Vol. 52  (1) , 73-78
Abstract
A case report of a 25-yr-old female with a sex cord stromal virilizing ovarian tumor is presented. The pathway of ovarian steroid secretion in this tumor is elucidated with the dominant elements being pregnenolone, 17-hydroxypregnenolone, 17-hydroxyprogesterone, androstenedione [A] and testosterone [T]. The tumor primarily made with lesser elevations of A, dehydroepiandrosterone (DHEA) and dihydrotestosterone (DHT). Expert pathologic opinions differed whether this neoplasm was a Sertoli-Leydig tumor or a virilizing granulosa tumor. It was probably a gynandroblastoma. A unilateral salpingoophorectomy was performed and the patient promptly resumed normal ovarian function with ovulation.

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