Familial Benign Intracranial Hypertension and Depression

Abstract
Two sisters developed benign intracranial hypertension (BIH) 2 wk following the resolution of a major depressive episode. The association of BIH and a major affective disorder in genetically related individuals has not been previously reported. Both conditions are associated with disturbances in the hypothalamic-pituitary-adrenal axis. Falling corticosteroid levels in a resolving depression may result in impaired CSF absorption and subsequent BIH.