Metabolism of ethylmalonate to mesaconate in the rat. Evidence for trans-dehydrogenation of methylsuccinate
- 15 August 1983
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 214 (2) , 641-644
- https://doi.org/10.1042/bj2140641
Abstract
Rats excrete increased ethylmalonate and methylsuccinate when given ethylmalonate in the diet; when given methylsuccinate they excrete methylsuccinate and mesaconate. Tenfold more labelled mesaconate was produced from threo-methyl[2,3-2H2] succinate precursor than from the erythro isomer. Our findings suggest trans-dehydrogenation of methylsuccinate and are the first direct evidence linking the metabolism of ethylmalonate, methylsuccinate and mesaconate.This publication has 7 references indexed in Scilit:
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