Changes in Total Body Calcium on Prolonged Maintenance Hemodialysis with High and Low Dialysate Calcium

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Abstract
In vivo neutron activation analysis was used to measure sequential changes in total body calcium in 25 un-selected patients with end-stage renal disease on dialysis for a period as long as 5 years. In 7 unselected patients (group 1), dialysis with a calcium solution of 5.0 mg/100 ml resulted in significant calculated daily loss of calcium ( – 321 ± SEM 76 mg/day) while dialysis with 6.5 mg/l00 ml resulted in a significant calculated calcium gain (182 ± SEM 103 mg/day; p < 0.0025). The remaining 18 patients (group 2) were dialyzed with a dialysate calcium of 6.5 mg/l00 ml and sequential total body calcium measurements showed no significant calcium losses (? 12 ± SEM 68 mg/day) for a period as long as 2 years.

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