Depression, antidepressants and suicidality: a critical appraisal
- 1 February 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Drug Discovery
- Vol. 4 (2) , 165-171
- https://doi.org/10.1038/nrd1634
Abstract
Regulatory agencies in the United Kingdom and United States have been critically examining the possible link between suicidality and antidepressant use in children and adults, which has resulted in an FDA directive to the manufacturers of all antidepressant medications to add a 'black box' warning that describes the increased risk of suicidal behaviour in children and adolescents who take antidepressants. A crucial issue in this debate, as we discuss here, is the assessment of the capacity of antidepressants to increase suicidality over and above what is caused by the underlying disorder, major depression, which is itself the principal cause of suicide.Keywords
This publication has 32 references indexed in Scilit:
- Biology of DepressionPublished by Wiley ,2005
- From monoamines to genomic targets: a paradigm shift for drug discovery in depressionNature Reviews Drug Discovery, 2004
- Suicide, suicidality and suicide prevention in affective disordersActa Psychiatrica Scandinavica, 2003
- Prevalence and comorbidity of affective disorders in persons making suicide attempts in Hungary: importance of the first depressive episodes and of bipolar II diagnosesJournal of Affective Disorders, 2003
- Human Drug Metabolism and the Cytochromes P450: Application and Relevance of In Vitro ModelsThe Journal of Clinical Pharmacology, 2001
- Functionally Active Duplications of the CYP2D6 Gene Are More Prevalent among Larynx and Lung Cancer PatientsOncology, 2001
- Research and treatment approaches to depressionNature Reviews Neuroscience, 2001
- Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.Proceedings of the National Academy of Sciences, 1993
- Mental disorders and comorbidity in suicideAmerican Journal of Psychiatry, 1993
- Comorbidity of mental disorders in the post-mortem diagnosis of completed suicide in children and adolescentsJournal of Affective Disorders, 1988