REVERSIBLE METABOLISM AND PHARMACOKINETICS - APPLICATION TO PREDNISONE-PREDNISOLONE

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 32  (3) , 387-405
Abstract
The simplest 3 pharmacokinetic models which apply in cases of reversible metabolism are described. Area under the curve (AUC) relationships are described which enable a choice of which one of the 3 models may apply in a particular case. Expressions for clearances and other pharmacokinetic parameters are given. Biexponential time courses are expected after bolus i.v. administration although distribution is not involved in the models. In some cases dose/AUC or infusion rate/steady-state concentration yield simple clearances; in other cases they are complex. AUC data obtained following oral administration of 5 mg doses of prednisone and prednisolone to 16 normal volunteers were analyzed with the new concepts and one of the models applied. This new interpretation of such data results in some significant changes from application of classical pharmacokinetics.