Dual effect of clomiphene citrate on pituitary gonadotropin secretion in postmenopausal women.

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Abstract
Fifteen postmenopausal women were given orally 25 mg or 50 mg of clomiphene citrate daily for 3 consecutive days. Significant (P < 0.01) decrease of serum LH [luteinizing hormone] (73%, 65%) and FSH [follicle stimulating hormone] (76%, 76%) resulted after administration of 25 mg and 50 mg clomiphene citrate, respectively. The suppressive effect was sustained for at least 4 days after cessation of this drug. Decreased LH and FSH levels after administration of ethinyl estradiol increased again by simultaneous administration of clomiphene citrate. Estrogenic effects of clomiphene citrate are probably observed in untreated estrogen deficient subjects, but anti-estrogenic effects are evident when serum estrogen levels are restored in subjects with estrogen deficiency.