Acute Effects of Prostaglandins on the Biosynthesis of Connective Tissue Constituents in the Non‐Pregnant Human Cervix Uteri

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Abstract
Biochemical effects of prostaglandins (PG) on the connective tissue of the human cervix uteri were studied by measuring the net incorporation of [3H] glycine and [3H] glucosamine into cervical specimens, incubated in vitro in the presence of PGE2 and PGF2.alpha.. The net readiolabeling with these isotopes, precursors of collagen and proteoglycans, was influenced by PGE2 and PGF2.alpha. in a similar manner. In the follicular phase of the menstrual cycle, both PG induced a decreased radiolabeling with glycine but caused an increased labeling with glucosamine. In the luteal phase, the situation was reversed, i.e., the incorporation of glycine was augmented and that of glucosamine was reduced in tissue incubated with PG. PG apparently can modulate the fibroblast biosynthesis activity in such a way that either the synthesis of fibrous structures (collagen) or that of ground substance constituents (proteolglycans) is favored.