Recessive Inheritance of Rapid Anti-Allotype Antibody Production
Open Access
- 1 August 1971
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 107 (2) , 389-393
- https://doi.org/10.4049/jimmunol.107.2.389
Abstract
BALB/c mice made antibody against an allotype determinant of C57 immunoglobulin after only three injections of non-agglutinated serum. Evidence was obtained indicating that the determinant was carried by the γG2a globulin class. C3H and CBA mice did not produce anti-allotype antibody when submitted to the injection schedule to which BALB/c animals responded. The results of treating F1 and backcross mice demonstrated that the strain difference was under polygenic control.Keywords
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