Rat Bladder Irrigation with PVP-I 2

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Abstract
Despite technical advances, Foley catheter associated urinary tract infections continue to be the leading cause of nosocomial infections. PVP-I2 is nonirritating to abraded tissue and it was shown that dilute solutions are bactericidal for organisms causing Foley catheter associated urinary tract infections. The purpose of this study was to ascertain the toxicity of PVP-I2 on the catheterized rat bladder and to measure the systemic I2 absorption. Bladder catheters were surgically placed into each of 3 groups of rats: group 1, catheters only; group 2, irrigation with PBS every 8 h; and group 3, irrigation with a 1:3 dilution of a 10% PVP-1% I2 solution every 8 h. One-half of each group was sacrificed at 1 and 2 wk, respectively. Photographs of mounted bladders and histologic sections were then graded by 3 independent observers. Blood for protein bound I (PBI), T3 [triiodothyronine] and T4 [thyroxine] levels was obtained before the study and at sacrifice. No difference in ulcerations, erythema or inflammation was noted. PBI was higher in group 3 rats at conclusion than group 1 and 2 (6.88 mg/dl vs. 3.42 mg/dl) (P < 0.05). There was no difference in T3 or T4 levels. Evidently, PVP-I2 was no more toxic to the bladder than catheterization alone or irrigation with PBS [phosphate buffered saline].

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