Tumors of the Esophagus and Duodenum Induced in Mice by Oral Adm.inistration of N-Ethyl-N′-Nitro-N-Nitrosoguanidine2

1 February 1974

journal article
Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute

Vol. 52 (2) , 519-522
https://doi.org/10.1093/jnci/52.2.519

Abstract

N-Ethyl-N′-nitro-N-nitrosoguanidine (ENNG) fed in drinking water to CBA/H-T6 mice produced squamous cell carcinomas of the esophagus and adenocarcinomas of the duodenum in about one-third of the animals over a period of 355–540 days. Many of the tumors invaded the adjacent organs.

Keywords

DRINKING
DUODENUM
ESOPHAGUS
FED
ADJACENT
ENNG
INVADED
NITROSOGUANIDINE2

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