A Stereoselective Synthesis of (R)-(-)-rolipram from L-Glutamic Acid
- 1 May 1997
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1997 (05) , 559-562
- https://doi.org/10.1055/s-1997-3182
Abstract
A stereoselective synthesis of (R)-(-)-rolipram from L-glutamic acid is described. The key step is a stereoselective Michael addition of an arylcuprate to a modified pyroglutamic derivative which acts as the template to induce the stereoselectivity. Facile manipulation of the enantiomerically pure Michael product afforded the expected therapeutic agent.Keywords
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