Reactions of sulphur nucleophiles with activated derivatives of clavulanic acid
- 1 January 1978
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 11,p. 467-468
- https://doi.org/10.1039/c39780000467
Abstract
Allylic halides (e.g.2), prepared from 4-nitrobenzyl clavulanate, react with salts of thiocarboxylic, thiocarbamic, and sulphinic acids to give thioesters, thiocarbamates, and sulphones; dehydrohalogenation of the halides affords the diene (4), from which sulphur derivatives may also be prepared via a stereospecific 1,4-addition reaction.Keywords
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