Lactulose in the Treatment of Chronic Portal-Systemic Encephalopathy
- 21 August 1969
- journal article
- clinical trial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 281 (8) , 408-412
- https://doi.org/10.1056/nejm196908212810803
Abstract
Current methods of controlling chronic portal-systemic encephalopathy (PSE) are unsatisfactory. Recently, lactulose treatment has been proposed. This synthetic disaccharide, which is neither absorbed nor hydrolyzed in the small bowel, is degraded by colonic bacteria, decreasing the pH of the colonic contents.Keywords
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