Some observations on the absorption and excretion of 4:6-dinitro-o-cresol (DNOC). 1. Blood dinitro-o-cresol levels in the rat and the rabbit following different methods of absorption

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Abstract
(3,5-dinitro-o-cresol in American usage) can be absorbed into the blood of rats and rabbits by ingestion, by inhalation, and through the skin. The rat can maintain significant blood DNOC levels following repeated daily doses of 5-20 mg./kg. Definite accumulation of DNOC in the blood occurs with 2 daily doses, but thereafter repeated daily doses cause very slight increases or decreases which are of doubtful significance. An apparatus is descr. for producing a DNOC aerosol. The rabbit can absorb DNOC through the skin. Repetition of the application caused increases in blood DNOC levels. At levels pf about 100 ug. DNOC/g. of blood rats may die either as a result of further doses of DNOC, or as the result of an increase in the environmental temp. Increases in environmental temps. cause increased mortality of rats dosed with DNOC, but they do not cause any significant changes in blood DNOC levels.