Contrasts for Identifying the Minimum Effective Dose
- 1 September 1989
- journal article
- research article
- Published by JSTOR in Journal of the American Statistical Association
- Vol. 84 (407) , 816
- https://doi.org/10.2307/2289672
Abstract
Dose-response studies are frequently used to study the effects of an experimental compound on various responses. One characteristic of the compound that is frequently of interest is the minimum effective dose (MED). Generally, inference about the MED is made by comparing various dose groups with a control (Dunnett 1955; Williams 1971). This article examines two families of contrasts used for related problems, and proposes a new family of contrasts (called basin contrasts) designed specifically for identifying the MED. Monte Carlo studies are used to demonstrate the superiority of the contrast procedures and make recommendations for their use.Keywords
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