THE DIURNAL RHYTHM IN WATER AND MINERAL EXCHANGE 1

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Abstract
Complete studies were made of the day and the night balance of water, minerals, and N for 40 consecutive days in 2 children with mild epilepsy. A negative balance of water was noted during the day; it was associated with increased elimination in the urine of water, Na, K, Cl, "total inorganic acid," "total base," and N. In dehydration, the diurnal rhythm of Na is temporarily reversed, with night excretion exceeding that of the day period. In fasting, the K rhythm may be reversed. The mechanism involved seems to be dependent upon the difference between the sleeping and the waking states.

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