A Study of the Stability of Pertussis Vaccine Under Different Conditions of Storage

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Abstract
The stability of pertussis vaccines killed by merthiolate, phenol, formalin, and heat was studied by means of mouse protection tests. Stored in the cold, some of the vaccines retained mouse protective properties for as long as from 8 to 10 years. The results suggest that heat at 56[degree] C for an hour should be reconsidered as a killing method. A vaccine dried from the frozen state showed no evidence of deterioration after 10 years; the suitability of such a preparation for a reference vaccine is discussed.