PLATELET-AGGREGATION, BETA-THROMBOGLOBULIN AND PLATELET FACTOR-4 IN DIABETES-MELLITUS AND IN PATIENTS WITH VASCULOPATHY

  • 1 January 1984
    • journal article
    • research article
    • Vol. 52  (3) , 236-239
Abstract
There were 155 subjects studied: 48 normals, 36 diabetics without complications, 44 with complications and 27 patients with macroangiopathy. .beta.-Thromboglobulin (.beta.-TG) and platelet factor 4 (PF4) were elevated in the patients groups. There was no correlation between the plasma levels of .beta.-TG and the stages of either retinopathy, macroangiopathy or nephropathy. The difference was more marked between normals and diabetics with neuropathy (P = 0.026). The aggregation response to ADP and platelet activating fctor (PAF) was enhanced at lower stimulator concentrations. Using the .beta.-TG, PF4 and aggregation values the discriminant analysis allows a distinction of several subgroups especially with nephropathy and neuropathy.