MOTILIN AND MIGRATING MYOELECTRIC COMPLEXES IN THE PIG AND THE DOG

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Abstract
Associations between migrating myoelectric complexes (m.m.c.s) and peak plasma motilin concentrations were confirmed in the dog fasted 18 h and was not in pigs fasted 3-4 h. Infusions of both natural porcine and synthetic 13-Nle-motilin failed to induce m.m.c.s in the pig. It was confirmed that motilin infusions stimulated the premature appearance of m.m.c.s in the dog whether motilin remained within, or exceeded, its normal plasma values. Immunoneutralization by i.v. administration of rabbit antimotilin serum was without effect on naturally occurring m.m.c.s in the dog and the pig. In the dog antimotilin serum blocked production of m.m.c.s by exogenous motilin for 7-10 days post-immunoneutralization. There are both species differences in associations of m.m.c.s and plasma motilin concentration, and an independence of m.m.c.s from plasma motilin even in the dog in which normally exogenous motilin can produce m.m.c.s.