The C4 ?-chain: Evidence for a genetically determined polymorphism
- 1 August 1983
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 64 (2) , 186-188
- https://doi.org/10.1007/bf00327123
Abstract
Using sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) five different β-chain patterns of denaturated human C4 were observed: C4βH, βH>L, βH=L, β H<L, and β L. In 32 families with 174 offspring the segregation of C4 β-chain types followed that of the other major histocompatibility complex (MHC) markers. It is concluded that the C4 β-chain patterns represent a genetically determined polymorphism, coded within the known C4A and B gene region.Keywords
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